CYP11B2 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD217738A
Western blot analysis of HEPG2 cell lysate using CYP11B2 Polyclonal Antibody at dilution of 1:650
Immunohistochemistry of paraffin-embedded Human brain tissue using CYP11B2 Polyclonal Antibody at dilution of 1:70(×200)
Product Name
CYP11B2 Polyclonal Antibody
Catalog Number
RD217738A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.
Immunogen Information
Immunogen
Synthetic peptide of human CYP11B2
Swissprot
P19099
Synonyms
ALDOSAldosterone synthaseAldosterone-synthesizing enzymeC11B2CYP11B2CYPXIB2Cytochrome P-450AldoCytochrome P-450C18Cytochrome P450 11B2Cytochrome P450 11B2mitochondrialmitochondrialP-450AldoP-450C18Steroid 18-hydroxylase
Calculated MW
58 kDa
Observed MW
Refer to figures
Gene Accession
NP000489
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas