FLNA Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD71171A
Western Blot analysis of HuvEc cells using FLNA Polyclonal Antibody at dilution of 1:2000.
Product Name
FLNA Polyclonal Antibody
Catalog Number
RD71171A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthesized peptide derived from human Filamin 1 around the non-phosphorylation site of Ser2152.
Swissprot
P21333
Synonyms
ABP 280ABP-280Actin-binding protein 280Alpha filaminAlpha-filaminAPBXCSBSCVD1Endothelial actin binding proteinEndothelial actin-binding proteinFilamin 1Filamin A alphaFilamin AFilamin-1Filamin-AFLNFLN-AFLN1FLNAFLNAFMDMNSNHBPNon musc
Calculated MW
281 kDa
Observed MW
280 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas