The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.
Immunogen Information
Immunogen
Synthetic peptide of human IGF2BP3
Swissprot
O00425
Synonyms
Cancer/testis antigen 98CT98DKFZp686F1078hKOCIF2B3IGF II mRNA binding protein 3IGF-II mRNA-binding protein 3IGF2 mRNA binding protein 3IGF2 mRNA-binding protein 3IGF2BP3IMP 3IMP-3Insulin like growth factor 2 mRNA binding protein 3Insulin-like