SOX-2 Monoclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD90638A
Immunohistochemistry of paraffinembedded Human esophageal squamous cell carcinoma with SOX-2 Monoclonal Antibody(Antigen repaired by EDTA).
Product Name
SOX-2 Monoclonal Antibody
Catalog Number
RD90638A
Clonality
Monoclonal
Host
Rabbit
Background
The SOX2 gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors, which plays an important role in early organ development. SOX2 can be used in the auxiliary diagnosis of germ cell tumors. 90% of embryonic cancers express SOX2, but not in seminoma, yolk sac tumor and choriocarcinoma. SOX2 has been shown to be a negative prognostic factor and associated with aggressive phenotypes in breast, head and neck, gastric, colorectal and bladder cancers. In small cell lung cancers, SOX2 was also correlated with a poor prognosis. Conversely, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and was shown to be an independent positive prognostic marker.
Immunogen Information
Swissprot
P48431
Synonyms
ANOP3cb236Delta EF2alccMCOPS3MGC148683MGC2413RGD1565646Sex determining region Y box 2SOX 2Sox2SOX2SRY (sex determining region Y) box 2SRY box containing gene 2SRY related HMG box 2SRY related HMG box gene 2SRY-box 2Transcription factor SO
Applications
Reactivity
Human
Tested Applications
IHC-P
Conjugation
Unconjugated
Storage Instructions
The concentrated should be stored at -20°C protecting from light,The RTU should be stored at 2~8°C protecting from light (Do not freeze).Valid for 12 months.