The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Full length fusion protein
Swissprot
Q96AJ9
Synonyms
MMDS3MVti1SNARE Vti1a beta proteinVesicle transport through interaction with t-SNAREs homolog 1AVesicle transport through interaction with tSNAREs homolog 1A (yeast)Vesicle transport v-SNARE protein Vti1-like 2Vti1 rp2Vti1-rp2Vti1aVTI1A vesicle