(KO Validated) MAP2K2 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD81904A
Western blot analysis of extracts of HeLa cells using MAP2K2 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of HeLa cells using MAP2K2 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts from normal (control) and MAP2K2 knockout (KO) 293T cells using MAP2K2 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts from normal (control) and MAP2K2 knockout (KO) 293T cells using MAP2K2 Polyclonal Antibody at dilution of 1:1000.
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Overview

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Product Name
(KO Validated) MAP2K2 Polyclonal Antibody
Catalog Number
RD81904A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Immunogen Information

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Immunogen
A synthetic peptide of human MAP2K2 (NP_109587.1).
Gene ID
5605
Swissprot
P36507
Synonyms
CFC4MAPKK2MEK2MKK2PRKMK2MAP2K2
Calculated MW
44 kDa
Observed MW
50 kDa

Applications

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Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

Research Areas

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