AADAC Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD77647A
Western Blot analysis of Human fetal liver and liver cancer tissue using AADAC Polyclonal Antibody at dilution of 1:550
Immunohistochemistry of paraffin-embedded Human colon cancer using AADAC Polyclonal Antibody at dilution of 1:30
Immunohistochemistry of paraffin-embedded Human liver cancer using AADAC Polyclonal Antibody at dilution of 1:30
Product Name
AADAC Polyclonal Antibody
Catalog Number
RD77647A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens. Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.
Immunogen Information
Immunogen
Recombinant protein of human AADAC
Swissprot
P22760
Synonyms
AAADAadaAadacArylacetamide deacetylase (esterase)Arylacetamide deacetylaseCES5A1DAC
Calculated MW
46 kDa
Gene Accession
BC032309
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas