The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
Immunogen Information
Immunogen
Synthetic peptide of human ABCC2
Swissprot
Q92887
Synonyms
ABC30abcC2ATP binding cassette sub family C (CFTR/MRP) member 2ATP binding cassette subfamily C member 2ATP-binding cassette sub-family C member 2Canalicular multidrug resistance proteinCanalicular multispecific organic anion transporter 1CMOATCMO
Gene Accession
NP_000383
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-150, ELISA 1:2000-10000
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4