This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14
Immunogen Information
Immunogen
Synthetic peptide of human ABI1
Swissprot
Q8IZP0
Synonyms
Abelson interactor 1Abi-1Abi1ABI1Abl binding protein 4Abl interactor 1Abl interactor protein 1Abl-binding protein 4AblBP4e3B1Eps8 binding proteinEps8 SH3 domain binding proteinEps8 SH3 domain-binding proteinEps8-binding proteinHssh3bp1Inter
Calculated MW
55 kDa
Gene Accession
NP_005461
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4