ABI2 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD88072A
Western blot analysis of extracts of various cell lines using ABI2 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using ABI2 Polyclonal Antibody at 1:1000 dilution.
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For more information on our kits, please contact us at info@reddotbiotech.com

Overview

Circle
Product Name
ABI2 Polyclonal Antibody
Catalog Number
RD88072A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity. Also required for nascent adherens junction assembly in epithelial cells.

Immunogen Information

Circle
Immunogen
A synthetic peptide of human ABI2
Gene ID
10152
Swissprot
Q9NYB9
Synonyms
ABI2ABI-2ABI2BAIP-1AblBP3SSH3BP2argBP1argBPIAargBPIB
Calculated MW
35kDa/36kDa/67kDa
Observed MW
55kDa

Applications

Circle
Reactivity
Human,Mouse
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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