May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Immunogen Information
Immunogen
Fusion protein of human ABI2
Swissprot
Q9NYB9
Synonyms
Abelson interactor 2ABI 2Abi-2ABI2ABI2ABI2BAbl binding protein 3Abl interacting protein 1 (SH3 containing protein)Abl interactor 2Abl interactor protein 2bAbl-binding protein 3AblBP3AIP 1Arg binding protein 1Arg protein tyrosine kinase bindi