The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Immunogen Information
Immunogen
Recombinant protein of human ABL1
Swissprot
P00519
Synonyms
Abelson murine leukemia viral oncogene homolog 1Abelson tyrosine protein kinase 1Abl 1ABLABL proto oncogene 1 non receptor tyrosine kinaseABL1ABL1bcr/ablbcr/c abl oncogene proteinc ABLc abl oncogene 1 non receptor tyrosine kinasec abl oncogene
Gene Accession
BC117451
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4