AF/LE Purified Anti-Mouse CD279/PD-1 Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD21637F
Product Name
AF/LE Purified Anti-Mouse CD279/PD-1 Antibody
Catalog Number
RD21637F
Clonality
Monoclonal
Isotype
Rat IgG2a, κ
Host
Rat
Background
CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
Immunogen Information
Gene ID
18566
Swissprot
Q02242
Synonyms
PD-1Programmed Death-1
Applications
Reactivity
Mouse
Tested Applications
FCM,Block,Neut
Conjugation
None (Purified antibody-Azide Free/Low endotoxin)
Concentration
0.5 mg/mL
Storage Buffer
0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Storage Instructions
Store at 2~8°C. Do not freeze.
Research Areas