AF/LE Purified Anti-Mouse CD54 Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD20339F
Product Name
AF/LE Purified Anti-Mouse CD54 Antibody
Catalog Number
RD20339F
Clonality
Monoclonal
Isotype
Rat IgG2b, κ
Host
Rat
Background
CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.
Immunogen Information
Gene ID
15894
Swissprot
P13597
Synonyms
Intercellular adhesion molecule 1Icam1MALA-2MyD10CD54Icam-1
Applications
Reactivity
Mouse
Tested Applications
FCM
Conjugation
None (Purified antibody-Azide Free/Low endotoxin)
Concentration
0.5 mg/mL
Storage Buffer
0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Storage Instructions
Store at 2~8°C. Do not freeze.
Research Areas