AF488 Anti-Human CD192/CCR2 Antibody[K036C2]

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
Staining of normal human peripheral blood cells with AF488 Anti-Human CD192/CCR2 Antibody[K036C2] (filled gray histogram) or AF488 Mouse IgG2a, κ Isotype Control (empty black histogram). Cells in the monocytes gate were used for analysis.
Staining of normal human peripheral blood cells with AF488 Anti-Human CD192/CCR2 Antibody[K036C2] (filled gray histogram) or AF488 Mouse IgG2a, κ Isotype Control (empty black histogram). Cells in the monocytes gate were used for analysis.
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Overview

Circle
Product Name
AF488 Anti-Human CD192/CCR2 Antibody[K036C2]
Catalog Number
RD30856F
Clonality
Monoclonal
Isotype
Mouse IgG2a, κ
Host
Mouse

Background

Circle
CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.

Immunogen Information

Circle
Gene ID
729230
Synonyms
CKR2CCR2ACCR2BCKR2ACKR2BCMKBR2MCP-1-RCC-CKR-2

Applications

Circle
Reactivity
Human
Tested Applications
FCM
Conjugation
AF488
Concentration
5 μL/Test
Storage Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage Instructions
This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.

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