AF488 Anti-Human CD193/CCR3 Antibody[5E8]
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Human peripheral blood granulocytes are stained with APC Anti-Human CD16 Antibody and AF 488 Anti-Human CD193/CCR3 Antibody (Left). Granulocytes are stained with APC Anti-Human CD16 Antibody and AF 488 Mouse IgG2b,κ Isotype Control (Right).
Product Name
AF488 Anti-Human CD193/CCR3 Antibody[5E8]
Catalog Number
RD30679F
Isotype
Mouse IgG2b, κ
Host
Mouse
Background
CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-alpha receptor like-2, and eotaxin receptor, is a member of the G protein-coupled seven transmembrane receptors family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CCR3 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CCR3 receptor is expressed on human eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, CD34+?hematopoietic progenitor cells, Th2-like lymphocytes, and keratinocytes. CCR3 is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types.
Immunogen Information
Gene ID
1232
Synonyms
CC CKR3MIP1-alpha receptor like-2eotaxin receptorCCRC-C chemokine receptor type 3
Applications
Reactivity
Human
Tested Applications
FCM
Conjugation
AF488
Concentration
5 μL/Test
Storage Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage Instructions
This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.