AF488 Anti-Human CD40 Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD20566F
Human peripheral blood lymphocytes are stained with Anti-Human CD40 Monoclonal Antibody(AF488 Conjugated)(filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.
Product Name
AF488 Anti-Human CD40 Antibody
Catalog Number
RD20566F
Clonality
Monoclonal
Isotype
Mouse IgG2a, κ
Host
Mouse
Background
CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.
Immunogen Information
Gene ID
958
Swissprot
P25942
Synonyms
Tumor necrosis factor receptor superfamily member 5Cd40B-cell surface antigen CD40Bp50CD40L receptorCD40Tnfrsf5
Applications
Reactivity
Human
Tested Applications
FCM
Conjugation
AF488
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.