AF488 Anti-Human CD45RA Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD20722F
Human peripheral blood lymphocytes are stained with Anti-Human CD45RA Monoclonal Antibody (AF488 Conjugated)(filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.
Product Name
AF488 Anti-Human CD45RA Antibody
Catalog Number
RD20722F
Clonality
Monoclonal
Isotype
Mouse IgG2b, κ
Host
Mouse
Background
CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naïve T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines.
Immunogen Information
Gene ID
5788
Swissprot
P08575
Synonyms
Receptor-type tyrosine-protein phosphatase CPtprcL-CALy-5T200CD45
Applications
Reactivity
Human
Tested Applications
FCM
Conjugation
AF488
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.