AF488 Anti-Human CD86 Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD20261F
Human peripheral blood monocytes are stained with Anti-Human CD86 Monoclonal Antibody (AF488 Conjugated)(filled gray histogram). Unstained monocytes (empty black histogram) are used as control.
Product Name
AF488 Anti-Human CD86 Antibody
Catalog Number
RD20261F
Clonality
Monoclonal
Isotype
Mouse IgG1, κ
Host
Mouse
Background
CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.
Immunogen Information
Gene ID
942
Swissprot
P42081
Synonyms
T-lymphocyte activation antigen CD86Cd86Activation B7-2 antigenEarly T-cell costimulatory molecule 1ETC-1
Applications
Reactivity
Human
Tested Applications
FCM
Conjugation
AF488
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Research Areas