AF488 Anti-Human CD8a Antibody[HIT8a]
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Human peripheral blood lymphocytes are stained with APC Anti-Human CD4 Antibody and AF 488 Anti-Human CD8a Antibody (Left). Lymphocytes are stained with APC Anti-Human CD4 Antibody and AF 488 Mouse IgG1, κ Isotype Control (Right).
Product Name
AF488 Anti-Human CD8a Antibody[HIT8a]
Catalog Number
RD30664F
Isotype
Mouse IgG1, κ
Host
Mouse
Background
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3?domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Immunogen Information
Gene ID
925
Synonyms
T-cell surface glycoprotein CD8 alpha chainCD8AT8Leu2MAL
Applications
Reactivity
Human
Tested Applications
FCM
Conjugation
AF488
Concentration
5 μL/Test
Storage Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage Instructions
This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.