AF488 Anti-Mouse CD103 Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
C57BL/6 murine splenocytes are stained with Anti-Mouse CD103 Monoclonal Antibody (AF488 Conjugated)[Used at 0.2 μg/10<sup>6</sup> cells dilution](filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.
C57BL/6 murine splenocytes are stained with Anti-Mouse CD103 Monoclonal Antibody (AF488 Conjugated)[Used at 0.2 μg/106 cells dilution](filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.
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Overview

Circle
Product Name
AF488 Anti-Mouse CD103 Antibody
Catalog Number
RD21027F
Clonality
Monoclonal
Isotype
Rat IgG2a, κ
Host
Rat

Background

Circle
CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Immunogen Information

Circle
Gene ID
16407
Swissprot
Q60677
Synonyms
Integrin alpha-EItgaeIntegrin alpha M290CD103

Applications

Circle
Reactivity
Mouse
Tested Applications
FCM
Conjugation
AF488
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

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