AF647 Anti-Mouse CD49b Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD21429F
C57BL/6 murine splenocytes are stained with Anrti-Mouse CD49b Monoclonal Antibody(AF647 Conjuaged)(filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.
Product Name
AF647 Anti-Mouse CD49b Antibody
Catalog Number
RD21429F
Clonality
Monoclonal
Isotype
Rat IgM, κ
Host
Rat
Background
DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.
Immunogen Information
Gene ID
16398
Swissprot
Q62469
Synonyms
Integrin alpha-2CD49 antigen-like family member BCollagen receptorPlatelet membrane glycoprotein IaGPIaVLA-2 subunit alphaCD49b
Applications
Reactivity
Mouse
Tested Applications
FCM
Conjugation
AF647
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Research Areas