AKT1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD70012A
Immunohistochemistry of paraffin-embedded Rat brain using AKT1 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Mouse brain using AKT1 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry analysis of paraffin-embedded Human Prostate using AKT1 Polyclonal Antibody.
Product Name
AKT1 Polyclonal Antibody
Catalog Number
RD70012A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Immunogen Information
Immunogen
Recombinant Human RAC-alpha serine/threonine-protein kinase protein
Swissprot
P31749
Synonyms
AKT 1AKTAKT1AKT1MGC99656PKBPKB-ALPHAPRKBAProtein Kinase B AlphaProtein kinase BProto-oncogene c-AktRAC AlphaRACRAC-alpha serine/threonine-protein kinaseRAC-PK-alpha
Gene Accession
BC000479
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:50-1:100
Concentration
2 mg/mL
Storage Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.