The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human APBA2
Swissprot
Q99767
Synonyms
Adapter protein X11betaAmyloid beta A4 precursor protein-binding family A member 2APBA2APBA2D15S1518EHsT16821LIN 10MGC:14091MGC99508Mint 2Mint-2MINT2Neuron-specific X11L proteinNeuronal Munc18-1-interacting protein 2Phosphotyrosine binding/i
Gene Accession
NP_001123886
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4