Human peripheral blood lymphocytes are stained with FITC Anti-Human CD3 Antibody and APC Anti-Human CD7 Antibody[HIT7] (Left). Lymphocytes are stained with FITC Anti-Human CD3 Antibody and APC Mouse IgG1, κ Isotype Control (Right).
CD7 is a 40 kD type I transmembrane glycoprotein also known as gp40. It is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL) and some acute myeloid leukemia (AML) cells. CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 costimulation can induce cytokine secretion and modulate cellular adhesion.