APC Anti-Mouse CD279/PD-1 Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD21649F
. Unstained splenocytes (empty black histogram) are used as control.](/upload/ec/antibodies/RD21649F-FC01.jpg)
Con-A stimulated C57BL/6 splenocytes (3 days) are stained with Anti-Mouse CD279/PD-1 Monoclonal Antibody(APC Conjugated)[Used at 0.2 μg/106 cells dilution](filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.
Product Name
APC Anti-Mouse CD279/PD-1 Antibody
Catalog Number
RD21649F
Clonality
Monoclonal
Isotype
Rat IgG2a, κ
Host
Rat
Background
CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
Immunogen Information
Gene ID
18566
Swissprot
Q02242
Synonyms
PD-1Programmed Death-1
Applications
Reactivity
Mouse
Tested Applications
FCM
Conjugation
APC
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Research Areas