C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks. Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro.
Immunogen Information
Immunogen
Recombinant protein of human APLF
Swissprot
Q8IW19
Synonyms
2010301N04RikAI452191AplfAPLFAprataxin and PNK-like factorApurinic-apyrimidinic endonuclease APLFC2orf13PNK and APTX like FHA proteinPNK and APTX-like FHA domain-containing proteinRGD1565557XIP1XRCC1 interacting protein 1XRCC1-interacting prot
Gene Accession
BC041144
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4