The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant protein of human ARFGAP1
Swissprot
Q8N6T3
Synonyms
ADP ribosylation factor 1 GTPase activating proteinADP ribosylation factor GTPase activating protein 1ADP-ribosylation factor 1 GTPase-activating proteinADP-ribosylation factor GTPase-activating protein 1ARF GAP 1ARF1 directed GTPase activating prote
Calculated MW
45 kDa
Gene Accession
BC028233
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:5000, IHC 1:25-1:100
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4