Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Immunogen Information
Immunogen
Recombinant protein of human ARHGEF7
Swissprot
Q14155
Synonyms
ARHG7ARHG7ARHGEF 7Arhgef7Beta pixBeta-PixbetaPixbetaPix-bbetaPix-cCoolCOOL-1COOL1DKFZp686C12170DKFZp761K1021KIAA0142KIAA0412mKIAA0142Nbla10314P50P50BPp85P85COOL1P85SPRPAK interacting exchange factor betaPAK-interacting exchange fac
Calculated MW
90 kDa
Gene Accession
BC060776
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4