This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.
Immunogen Information
Immunogen
Synthetic peptide of human ASCL1
Swissprot
P50553
Synonyms
Achaete scute complex homolog 1Achaete scute complex homolog like 1Achaete scute complex homologue 1Achaete scute complex homologue like 1Achaete scute complex like 1Achaete scute family bHLH transcription factor 1Achaete scute proteinAchaete-scute
Gene Accession
NP_004307
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.1 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4