This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Synthetic peptide of human ASPN
Swissprot
Q9BXN1
Synonyms
ASPNASPN proteinASPNAsporin (LRR class 1)AsporinAsporin proteoglycanFLJ20129LRR class 1Periodontal ligament associated protein 1Periodontal ligament-associated protein 1PLAP 1PLAP-1PLAP1SLRR 1CSLRR1CSmall leucine rich protein 1C
Calculated MW
43 kDa
Gene Accession
NP_001180264
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000 IHC 1:50-200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4