Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes.
Immunogen Information
Immunogen
Recombinant protein of human ATG4D
Swissprot
Q86TL0
Synonyms
9830134P12RikAPG4 autophagy 4 homolog DAPG4 DAPG4S. cerevisiaehomolog ofDAPG4DATG4 autophagy related 4 homolog D (S. cerevisiae)Atg4dATG4DAtg4dlAUT like 4 cysteine endopeptidaseAUT-like 4 cysteine endopeptidaseAUTL4Autophagin 4Autophagin-4
Gene Accession
BC007639
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4