The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
Immunogen Information
Immunogen
Synthetic peptide of human ATR
Swissprot
Q13535
Synonyms
Ataxia telangiectasia and Rad3 relatedAtaxia telangiectasia and Rad3-related proteinATRATRFCTCSFRAP Related Protein 1FRAP-related protein 1FRP1MEC1MEC1 mitosis entry checkpoint 1 homologProtein kinase ATRRAC3Rad3 related proteinSCKLSCKL1Ser