The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Immunogen Information
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse BAK
Swissprot
Q16611,O08734
Synonyms
Apoptosis regulator BAKBAKBAK likeBak NTBAKBak1Bcl 2 homologous antagonist/killerBcl 2 like 7 proteinBcl-2 homologous antagonist/killerBcl-2-like protein 7BCL2 antagonist/killer 1Bcl2 like 7 ProteinBcl2-L-7BCL2L7CDN1Cell death inhibitor 1M
Calculated MW
25 kDa
Observed MW
25 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
3.1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4