The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Immunogen Information
Immunogen
Recombinant protein of human BAX
Swissprot
Q07812
Synonyms
Apoptosis regulator BAXBAXBax-proteinBAXBAXABaxdelta2G9Baxdelta2G9omegaBaxdelta2omegaBcl-2-like protein 4BCL2 associated X proteinBCL2 associated X protein omegaBCL2 associated X protein transcript variant delta2Bcl2-L-4BCL2L4membrane isofor
Calculated MW
21 kDa
Gene Accession
BC014175
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4