BBC3 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD78435A
Western Blot analysis of A549 cell using BBC3 Polyclonal Antibody at dilution of 1:600
Variation
Quantity
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Overview
Product Name
BBC3 Polyclonal Antibody
Catalog Number
RD78435A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Synthetic peptide of human BBC3
Swissprot
Q9BXH1
Synonyms
BBC 3Bbc3BBC3BCL 2 binding component 3Bcl-2-binding component 3BCL2 binding component 3JFY 1JFY-1JFY1p53 up regulated modulator of apoptosisp53 up-regulated modulator of apoptosisp53 Upregulated Modulator of ApoptosisPUMA alphaPUMA/JFY1
Calculated MW
21 kDa
Gene Accession
NP_055232
Applications
Reactivity
Human
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000
Concentration
0.9 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas