BBC3 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD267059A
Western blot analysis of extracts of various cell lines using BBC3 Polyclonal Antibody at dilution of 1:1000.
Immunofluorescence analysis of NIH-3T3 cells using BBC3 Polyclonal Antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Product Name
BBC3 Polyclonal Antibody
Catalog Number
RD267059A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
A synthetic peptide of human BBC3 (NP_001120713.1).
Gene ID
27113
Swissprot
Q96PG8,Q9BXH1
Synonyms
BBC3JFY-1JFY1PUMA
Calculated MW
10 kDa/14 kDa/20 kDa/26 kDa
Observed MW
20 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IF
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000 IF 1:50-1:100
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.