BBC3 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD70215A
Immunohistochemistry of paraffin-embedded Human ovarian cancer using BBC3 Polyclonal Antibody at dilution of 1:100
Product Name
BBC3 Polyclonal Antibody
Catalog Number
RD70215A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Recombinant Human Bcl-2-binding component 3 protein
Swissprot
Q9BXH1
Synonyms
BBC 3Bbc3BBC3BCL 2 binding component 3Bcl-2-binding component 3BCL2 binding component 3JFY 1JFY-1JFY1p53 up regulated modulator of apoptosisp53 up-regulated modulator of apoptosisp53 Upregulated Modulator of ApoptosisPUMA alphaPUMA/JFY1
Applications
Reactivity
Human
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:100-1:200
Concentration
2 mg/mL
Storage Buffer
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas