This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
Immunogen Information
Immunogen
Synthetic peptide of human BCL2L2
Swissprot
Q92843
Synonyms
Apoptosis regulator BCL WApoptosis regulator Bcl-WB2CL2BCL 2 Like 2Bcl 2 like 2 proteinBcl 2L2BCL WBcl-2-like protein 2Bcl2 L2BCL2 like 2BCL2 like 2 proteinBcl2-L-2Bcl2l2BCLWKIAA0271PPP1R51Protein phosphatase 1 regulatory subunit 51