BECN1 Monoclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD85560A
Western Blot analysis of 1) 293T, 2) C2C12, 3) Rat brain using BECN1 Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Human brain tissue using BECN1 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using BECN1 Monoclonal Antibody at dilution of 1:200.
Product Name
BECN1 Monoclonal Antibody
Catalog Number
RD85560A
Clonality
Monoclonal
Purification Method
Protein A purification
Isotype
IgG
Host
Mouse
Background
Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
Immunogen Information
Immunogen
Synthetic Peptide of Beclin-1
Swissprot
Q14457
Synonyms
APG6ATG 6ATG6ATG6 autophagy related 6 homologBcl-2-interacting protein beclinBeclin 1 (coiled coil moesin like BCL2 interacting protein)Beclin 1 autophagy relatedBeclin-1Beclin1BECN 1Becn1BECN1Coiled coil myosin like BCL2 interacting proteinC
Observed MW
60 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p
Conjugation
Unconjugated
Dilution
WB 1:1000-2000, IHC 1:100-200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.