BECN1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD70303A
Immunohistochemistry analysis of paraffin-embedded human tonsil using BECN1 Polyclonal Antibody at dilution of 1:500.
Immunofluorescence analysis of paraffin-embedded mouse kidney using BECN1 Polyclonal Antibody at dilution of 1:300.
Product Name
BECN1 Polyclonal Antibody
Catalog Number
RD70303A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
Immunogen Information
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse Beclin1
Swissprot
Q14457,O88597,Q91XJ1
Synonyms
APG6ATG 6ATG6ATG6 autophagy related 6 homologBcl-2-interacting protein beclinBeclin 1 (coiled coil moesin like BCL2 interacting protein)Beclin 1 autophagy relatedBeclin-1Beclin1BECN 1Becn1BECN1Coiled coil myosin like BCL2 interacting proteinC
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,IF
Conjugation
Unconjugated
Dilution
IHC 1:300-1:1000, IF 1:100-1:500
Concentration
2.6 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.