HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kD α (heavy) chain and a 27 kD β (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells.
Immunogen Information
Gene ID
3122 ,3123
Swissprot
P01903,P01911
Synonyms
HLA class II histocompatibility antigen DR alpha/ DRB1-15 beta chainMHC class II antigen DRAHLA-DRA1/DRB1DRA/DRB1