CD11c is a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c forms a αXβ2 heterodimer with β2 integrin (CD18). It is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. The αXβ2 integrin plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen and CD54.
Immunogen Information
Gene ID
16411
Swissprot
Q9QXH4
Synonyms
Integrin alpha-XItgaxCD11 antigen-like family member CLeukocyte adhesion receptor p150+95CD11c