CD3, also known as T3, is a member of the Ig superfamily and primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3 is composed of CD3ε, δ, γ and ζ chains. It forms a TCR complex by associating with TCR α/β or γ/δ chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex.
Immunogen Information
Gene ID
12502
Swissprot
P04235,P11942,P22646,P24161
Synonyms
T-cell surface glycoprotein CD 3epsilon/delta/gamma/zeta chainCD3E/D/G/ZCD3e/d/g/zCD3E/D/G/ZCD3