Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis.Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule-kinetochore interactions were intact. Releasing Bod1-depleted cells from a monastrol block increases the frequency of syntelic attachments and the number of cells displaying biorientation defects.
Immunogen Information
Immunogen
Synthetic peptide of human BOD1
Swissprot
Q96IK1
Synonyms
Biorientation defective 1Biorientation defective protein 1biorientation of chromosomes in cell division 1Biorientation of chromosomes in cell division protein 1BOD1BOD1FAM44Bfamily with sequence similarity 44member BProtein FAM44B
Gene Accession
NP_001153123
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4