This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human BRAF
Swissprot
P15056
Synonyms
FLJ9510994 kDa B raf proteinB raf 1B Raf proto oncogene serine threonine protein kinaseB Raf proto oncogeneserine/threonine kinaseB RAF1B-Raf proto-oncogene serine/threonine-protein kinase (p94)BRAF 1BRAFBRAFBRAF1cRmilMGC126806MGC138284Muri
Calculated MW
84 kDa
Gene Accession
NP_004324
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4