This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Immunogen Information
Immunogen
Recombinant protein of human BRCA1
Swissprot
P38398
Synonyms
BRCA 1BRCA1BRCA1 DNA repair associatedBRCA1/BRCA2 containing complex subunit 1BRCA1/BRCA2-containing complexsubunit 1BRCA1BRCAIBRCC 1BRCC1Breast and ovarian cancer susceptibility protein 1Breast Cancer 1Breast Cancer 1 Early OnsetBreast cance
Gene Accession
BC072418
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4