This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
Immunogen Information
Immunogen
Recombinant fusion protein of human BUB1B
Gene ID
701
Swissprot
O60566
Synonyms
BUB1BBUB1betaBUBR1Bub1AMAD3LMVA1SSK1hBUBR1
Calculated MW
47kDa/52kDa
Observed MW
52kDa
Applications
Reactivity
Human,Mouse
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.