This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant protein corresponding to Mouse c-Kit
Swissprot
P10721,P05532
Synonyms
C Kitc-Kitc-Kit LigandCD117KitKit LigandKIT oncogeneKIT proto oncogene receptor tyrosine kinaseKITMast cell growth factor receptorMast/stem cell growth factor receptor KitMGFp145 c-kitPBTPiebald trait proteinProto oncogene c KitProto oncog
Calculated MW
110 kDa
Observed MW
145 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
3 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4