This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.
Immunogen Information
Immunogen
Synthetic peptide of human C12orf5
Swissprot
Q9NQ88
Synonyms
6-bisphosphatase TIGARC12ORF5chromosome 12 open reading frame 5FR2BPFructose-26-bisphosphatase TIGARFructose-26-bisphosphate 2-phosphataseProbable fructose 26 bisphosphatase TIGARProbable fructose-2tigarTIGARTP53 induced glycolysis and apopto
Gene Accession
NP_065108
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4